Ft Lauderdale FL – Guests sailing aboard Silver

first_imgFt. Lauderdale, FL – Guests sailing aboard Silver Spirit’s 91-day Grand Inaugural Voyage this month are set to enjoy an exclusive evening of entertainment when multiple Grammy Award-nominee Michael Feinstein takes to the stage. The performance will follow a gala bon voyage dinner to be held aboard Silver Spirit in Fort Lauderdale on January 20, the day before the ship embarks on an expansive journey exploring over 20 countries and 45 ports throughout the Americas — for the very first time.“Every detail of Silver Spirit’s Grand Inaugural Voyage has been designed with a highly discerning and experienced traveler in mind, and we want the onboard entertainment experience to be of equally exceptional caliber,” said Christian Sauleau, Silversea’s executive vice president of vessel operations. “We’re delighted to have such an extraordinary performer as Michael Feinstein on hand to help us celebrate the launch of our new flagship and what is sure to be the voyage of a lifetime for our guests.”An outstanding vocalist and pianist, Michael Feinstein is arguably the single most knowledgeable and dedicated musical anthropologist and archivist the Great American Songbook has ever known. Renowned for finding “lost,” older songs and breathing new life into them, his repertoire includes songs by such great songwriters as George Gershwin, Irving Berlin, Johnny Mercer, and Duke Ellington.His 150 plus shows a year have included Carnegie Hall, the Hollywood Bowl and major concert halls, as well as the White House and Buckingham Palace. At his nightclub in Manhattan, Feinstein’s at Loews Regency, a showcase for top-drawer cabaret performers, Feinstein plays to a sold-out crowd. The Sinatra Project – his new CD from Concord Records which celebrates the musical sensibilities of “Old Blue Eyes” – earned Feinstein his fifth Grammy Award nomination in 2009. He is currently preparing the PBS-TV series “Michael Feinstein’s American Popular Song” – to start airing in 2010 – in which Feinstein discovers treasures of the Great American Songbook around the world.The newest addition to Silversea’s ultra-luxury, six-ship fleet, Silver Spirit debuted in Europe in December and will host several days of inaugural activities in Fort Lauderdale when the 540-guest, all-suite ship arrives on January 19. Among the highlights is the Christening Ceremony scheduled to take place on January 21.Silversea Cruises is recognized as an innovator in the luxury segment, offering guests large-ship amenities aboard its intimate, all-suite vessels: Silver Cloud, Silver Wind, Silver Shadow, Silver Whisper and Silver Spirit — all designed to offer an atmosphere of conviviality and casual elegance. With the inclusion of the regal expedition ship Prince Albert II, the company’s itineraries encompass all seven continents.In the U.S., Silversea has been voted “World’s Best” by the readers of Condé Nast Traveler (nine times) and Travel + Leisure (seven times), and rated Number-One luxury cruise line by high-net-worth consumers in the 2008 Luxury Brand Status Index (LBSI). International awards include “Best Innovation in Products and Services” from the Italian Innovazione Marketing Oggi Awards (2009); “World’s Leading Small Ships Cruise Line” from World Travel Awards (2009); “Five Star Diamond Award” from the American Academy of Hospitality Sciences (2009); “Number One” small-ship line in the Readers’ Choice” survey conducted by Britain’s Condé Nast Traveller magazine (2007); “Best Luxury Cruise Line” by Spain’s Cruceros & Destinos magazine (2008); “Best Luxury Cruise Line” by Australia’s Luxury Travel & Style Magazine (2009); and “Best Luxury Cruise Operator” according to Asia’s Travel Weekly (2008).www.silversea.comlast_img read more

Peter Bazalgette TV industry veteran Sir Peter Baz

first_imgPeter BazalgetteTV industry veteran Sir Peter Bazalgette will become non-executive chairman  of ITV from early May, succeeding Archie Norman who is stepping down after a six-year tenure.Bazalgette has been a non-executive director of UK-listed commercial broadcaster ITV since June 2013. A stalwart of the UK TV business, he has served as chairman of Endemol UK and chief creative officer of Endemol Group.He is personally credited with creating the Ready Steady Cook and Changing Rooms formats, and with bringing Big Brother to the UK.Bazalgette has also been a non-exec director at Channel 4 and at the UK Department of Culture Media and Sport. He is also president of the Royal Television Society.He said today: “As I have seen for myself over the last few years, ITV has gone through a remarkable resurgence during Archie’s chairmanship and there is still so much more that we can achieve.“This is an incredibly exciting time for everyone in the media sector with change happening at an unprecedented rate, and I’m absolutely delighted to be working with Adam and the management team. TV is my first love.”ITV has enjoyed a change in fortunes with Norman as chair and Adam Crozier as CEO, and has expanded aggressively internationally. Speaking about Bazalgette’s appointment, Crozier said: “ITV is now clearly in a much stronger position creatively, commercially and financially than when we started out and we’re in great shape to take on the many opportunities and challenges ahead.“I’m really pleased that Peter, with his huge wealth of experience in television and the wider creative industries, will be with us as Chairman as we continue to grow and strengthen the business in the UK and internationally.”Norman joined ITV in 2009. A former Conservative Member of Parliament he was credited with turning around the fortunes of the Asda supermarket. He said today:  “The last six years has been undoubtedly challenging but also extremely rewarding and enjoyable, and an experience I would not have missed for the world.“The ITV I am leaving has a great track record, brilliant people and enormous potential for future growth. I leave it in the very best of hands.”Outside of TV Bazalgette is chair of Arts Council England and on the board of ad agency BBH.last_img read more

In addition to getting flashlights bottled water

first_imgIn addition to getting flashlights, bottled water and food, hurricane preparation these days includes stockpiling apps on your phone. For those in the path of Hurricane Florence in North and South Carolina, having the right apps can be lifeline during and after the storm. Here are some apps — mostly free — that are useful to download if you’re in a hurricane zone:For immediate assistance:Crowdsource Rescue – Emergency phone lines, like 9-1-1, can get overwhelmed with calls during storms, and this app helps with the rescue efforts through the concept of “neighbors rescuing neighbors.” The app was developed by Matthew Marchetti and Nate Larson as Harvey hit Houston too quickly to connect professional first-responders and vetted volunteers with all those in need of help. The app uses GPS tracking and allows civilian volunteers, such as those who may have a boat, to sign in and help evacuate others in the area. For shelter:Harmany – This app was created in 2017 after hurricanes Harvey and Irma to connect people in need of temporary shelters with those who want to provide it during emergencies and evacuation events. On the app, hosts can easily turn on and off their shelter spaces and evacuees can do a shelter search to find the best places to suit their needs. Harmany also provides in-app alerts and notifications for severe weather, fire, and other dangerous events.Airbnb — Through a program called OpenHomes Airbnb allows hosts to offer extra space for free to those in need of temporary housing. Airbnb then helps hosts by verifying, screening and checking guests, reimbursing hosts for any property damage, and providing phone support. Airbnb activated the OpenHomes program in Georgia, North Carolina, South Carolina, and Virginia for Hurricane Florence. These free listings will be available until October 1. For updates:Weather Underground – This app provides hyper-local forecasts and current conditions from local weather stations with customizable alerts. It also allows users to report local weather and hazards to help inform others in the community. The map interface is interactive, allowing users to choose different layers to view elements such as rain accumulation, crowd reports, and satellite images. It also allows users to track storms. FEMA – This app provides real-time alerts from the National Weather Service, helps users locate emergency shelters and disaster recovery centers and includes various safety tips to help people stay safe during a natural disaster. It allows users to register for disaster assistance online and share photos through FEMA’s disaster reporter. This app is available in both English and Spanish.Hurricane by the American Red Cross — This app allows users to monitor conditions in their area and let family and friends know they’re okay with the use of a customizable “I’m Safe” alert for Facebook, Twitter, email and text. The app includes a map where users can track the hurricane’s path and find Red Cross shelters in the area. If you don’t have data connectivity, the app also provides users step-by-step instructions of what to do before/during/after the storm. It also comes with a Hurricane Toolkit, with a strobe light, flashlight and audible alerts.iHeartRadio—For those who want to follow along with local news stations to get the latest updates, or who are radio nerds like us, this app will ensure that you can continue access broadcasts, so long as you have service. For communication:FireChat – No cell service? No internet? No problem. FireChat is a free messaging app that works without either of these things, relying on mesh networks instead. However, Bluetooth and WiFi still need to be turned on, even if access isn’t available, in order for this app to work. In the app, users can create private groups of up to 50 people or create public chat rooms using hashtags.Zello — Currently trending on Google Play and hitting the number one spot on the Apple App Store’s “free” apps, Zello is a push-to-talk app, sort of like a walkie-talkie. Unlike walkie-talkies, there are no limits to the number of users or channels. It’s available worldwide, wherever there’s WiFi or data service, and can be used like a two-way radio to communicate with family members or rescuers.Nextdoor – This is a locally driven app that keeps users informed about what’s going on in their neighborhood and connects them with their neighbors. The app provides a secure environment where all neighbors are verified, and was used during Hurricane Harvey. In the app, neighbors can discuss evacuation routes, flood levels, or ask for help from their neighbors, even when other emergency communication methods such as 9-1-1 are down. WhatsApp – During hurricanes or storms, telecommunication services can be limited, but WhatsApp connects to the internet to send messages between phones so that you can stay in touch with friends, family, and loved ones throughout the storm. It also allows you to do free voice and video calls. Glympse — This is a real-time location-sharing app that allows users to share their exact whereabouts with others, such as rescue groups. Local News Apps — Those in Hurricane Florence’s path can look up and download local news apps in order to get more local updates and information on the storm. (The WUNC app, for example).For supplies: GasBuddy – Normally, users can use the GasBuddy app to find the closest and cheapest gas stations in their area. However, GasBuddy has recently activated its fuel availability tracker so that residents in affected hurricane areas can find gas more easily. The tracker can differentiate between stations that have no power, limited fuel options, or no fuel, as opposed to those that have both fuel and power. These services can also be found outside the app here: http://tracker.gasbuddy.com.For well-being: Red Cross Apps – Red Cross offers a variety of apps that can be useful during hurricanes and other natural disasters. In addition to their Hurricane app, it has a Flood app that educates people on how to prepare for floods. In case of injury, they also have a First Aid app that informs users on how to handle common first aid emergencies (they even have one for pet emergencies).Headspace: Meditation — Meditating can be one form of self-care to relieve stress and stay calm. This app provides guided meditation sessions, and even includes an SOS feature for moments of panic, anxiety or stress. The app comes with a free trial before they start charging a subscription fee. Looking for a free alternative? Another option for a mindfulness app is Calm, which includes over 100 guided meditations and music geared to help you focus, relax and sleep.Amanda Morris is an intern on NPR’s National Desk. Copyright 2018 NPR. To see more, visit http://www.npr.org/.last_img read more

The new work and pensions secretary has suggested

first_imgThe new work and pensions secretary has suggested the government’s pledge to halve the disability employment gap will face lengthy delays, after he said he wanted to spend a “few years” testing how to achieve the target.Stephen Crabb, who was appointed after the resignation of Iain Duncan Smith in March, was giving evidence for the first time to the Commons work and pensions select committee.Tory ministers have repeatedly referred to their commitment to halving the gap of about 30 percentage points between the employment rates of disabled people (less than 50 per cent) and non-disabled people (about 80 per cent).Halving the gap would mean finding jobs for more than one million more disabled people.Last year’s general election manifesto said a Conservative government would “aim to halve the disability employment gap”, one of just eight mentions of the words “disabled” or “disability” in the 84-page document.Labour MP Neil Coyle (pictured during the session), a former director of Disability Rights UK, asked Crabb what “milestones” he would use to measure the success of the “very welcome and ambitious manifesto commitment” to halve the disability employment gap, when the proportion of working-age disabled people in work had fallen over the last six years.Disability Rights UK has stressed the importance of setting milestones, in its submission to the committee’s inquiry into halving the gap, pointing out that “interim targets could be expected to drive institutional change and it could be expected that the government would wish to know if it was on track”.But Crabb said that rather than setting interim targets for narrowing the gap, he wanted instead to focus on what policies might prove successful.He said that 150,000 more disabled people were in work in the last year, but if the number of non-disabled people in work had also risen “there is no closing of the gap”.He said he did not think that setting out interim targets towards achieving the aim of halving the gap was “the more helpful approach”, and added: “The more helpful approach I think is testing what works and building the evidence base for how we do that and that’s what I want to spend the next few years really focusing on.”He appeared then to criticise the approach of his predecessor as work and pensions secretary, by adding: “I don’t know that whatever has gone on before has really built a strong evidence base for supporting people with disabilities and health conditions into work.”Crabb told the committee that he wanted to “take a step back” from previous plans to publish a white paper with “firm legislative proposals” on supporting disabled people into work.Instead, he said, there would be a “much more discursive green paper that starts to reframe the issue and points the way towards more meaningful long-term reform”.And he said he wanted to “restart conversations with disability organisations and disabled people themselves about how best as a government we can work with them to close the disability employment gap”.When Crabb said later in the session that DWP would provide more disability experts in jobcentres, Coyle asked him to clarify what this increase meant, as the number of disability employment advisers fell by a fifth in the last parliament.In another criticism of the Duncan Smith regime, Crabb said DWP would be placing another 500 disability employment advisers into jobcentres across the country, which he said was “a significant step forward”.He said: “Whatever decisions happened in the last parliament, that was then.“I’m pretty clear in my mind, whether it’s by employing more of our own people as disability specialists or partnering with expert organisations, we need to get more expertise under the roof of Jobcentre Pluses, in terms of how we support people with sicknesses and disabilities, and addictions as well.”A Department for Work and Pensions spokesman said later that there was “no plan to abandon the target” of halving the disability employment gap.He said: “It is a long-term ambition, and the secretary of state was re-affirming government’s commitment to reducing the gap.”last_img read more

Madison Square Garden to Explore Splitting Into Two Companies

first_img –shares Madison Square Garden to Explore Splitting Into Two Companies Next Article Add to Queue Register Now » Image credit: littleny | Shutterstock.com Free Webinar | July 31: Secrets to Running a Successful Family Business Madison Square Garden Trends 2 min read This story originally appeared on Reuters Reuters October 28, 2014 Learn how to successfully navigate family business dynamics and build businesses that excel. Madison Square Garden Co, which owns the New York Knicks and New York Rangers, said Monday it is considering a plan to separate its entertainment business from its media and sports business to create two publicly traded companies.Shares of the company rose 14 percent in after-market trade.The company said the live entertainment division would be an event and venue management company, while the sports and media unit would run sports teams and regional sports television networks.”Investors favor companies with greater strategic focus on their core businesses,” Chief Executive Officer Tad Smith said in a statement.Madison Square Garden said its shareholders would own shares in both the new companies if it goes ahead with the spin-off. The company said the idea had been under consideration internally since July.The company also said its board authorized a plan to buy back Class A shares of up to $500 million.”We are very pleased that MSG’s board of directors and management have committed to pursue a plan to enhance value for all MSG shareholders through the combination of a share repurchase program and contemplated business spin-off…We look forward to the full and timely implementation of these plans,” JAT Capital Management LP said in an email to Reuters.JAT has a 9.36 percent stake in the company as of Sept. 22.The company said it has not set a timetable for the completion of the potential spin-off.Madison Square Garden hired LionTree Advisors as financial adviser for the separation.Madison Square Garden also nominated activist investor Nelson Peltz of Trian Fund management LP and Scott Sperling of private equity firm Thomas H. Lee Partners LP to join its board.Madison Square Garden shares closed at $65.78 on the Nasdaq on Monday.(Reporting by Soham Chatterjee in Bangalore and Greg Roumeliotis in New York; Editing by Cynthia Osterman)last_img read more

Disney Can Fly Drones After Unblocking Its Parks Nofly Zones

first_imgDisney Next Article And they’ve already got a spectacular planned for this holiday season. Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goals –shares Image credit: The Disney Blog via engadget Disney Can Fly Drones After Unblocking Its Parks’ No-fly Zones Add to Queue 2 min readcenter_img Register Now » David Lumb Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. This story originally appeared on Engadget Contributing Editor For their high price of admission, Disneyland and Disney World offer park-wide immersion and entertainment capped off with nightly shows and seasonal fireworks. Back in 2014, they applied for patents to augment these spectaculars with drones to carry screens or light pyrotechnics themselves. Today, they’ve finally gotten permission from the FAA to light up their happiest skies with UAVs, and already have shows planned for this winter. But getting there meant getting a special exception for the no-fly zone over its Florida park Disney got in the books a decade ago.That ban, acquired in the post-9/11 days when the Magic Kingdom lobbied for safety, hasn’t been extended to any of the other 400 amusement parks in the US. But as the Washington Post reported, Disney began lobbying the FAA to relax those rules, and allow it to fly drones during a fireworks show, with several employees monitoring dozens of autonomous drones. The agency’s exemption only applies until November 2020, and can be rescinded at any time. While it’s unclear what the parks plan to do with the drones, they released a teaser video for their first UAV spectacular to go up this holiday season: November 9, 2016last_img read more

How Data Quality Affects Good Marketing Decisions

first_imgHow Data Quality Affects Good Marketing Decisions Margarita NahatakyanJune 26, 2019, 9:00 amJune 25, 2019 As marketers, we get disappointed and frustrated whenever we launch a campaign that does not really succeed. Most of the time we get emails bouncing back into our inboxes, or worst, we get direct emails being sent back. Having our marketing campaigns backfire is sadly a common occurrence. We all go through this. However, it does not have to be this way. We can now invest all our time, funds and efforts, to high-quality data. Most of us spend years investing in bad quality data. We never really knew how quality data could affect marketing decisions. This is why we’re here to show you how top-quality data can greatly impact our organizations.We know where high – quality leads or customers are coming from.When we try to measure our awareness metrics, we usually opt to rely on the number of followers we have on social media platforms or how many visits our websites have in a day. However, we can’t rely on these numbers alone. Although helpful, this information does not really contribute much when it comes to business objectives.When we have top quality data, we get to see where our leads are most likely to be converted into existing customers. With good website visitor analytics, we can find out what traffic sources are producing converted leads. This way, we get to focus our time, funds and efforts on that specific traffic source. Good data also allows us to use our web analytics marketing tools – we not only get to see how effective our websites are but also how effective our marketing campaigns are.We get to see how engaged our customers are.With good quality data, we as marketers can determine how engaged our customers are with us. All this can be measured through how much time they spend on our websites, email open rates, and click-through-rates. We also get to see our content engagement rates. We can then determine which blog posts or subject matters engage our customers the most.We find out if our customers are happy.If we’ve recorded high-quality data we get to determine if our customers are happy or not. Most of the time, customer retention costs less than attracting and converting them. With accurate data, we get to see how we can keep our current customers. One of the best questions to ask your consumers to your customers is this, “Would you recommend our organization to others?”From their answers, we can determine if they are happy or not. If they are not, at least we know that we have things that need improvement. If they are happy, good. Let’s keep doing what we are doing.In a nutshell, when we gain high quality and accurate data, we can make key marketing decisions. When we know where our customers are coming from, we know what traffic sources to invest in more and which ones we need to improve. Knowing how engaged our consumers are can also help us in making better decisions. We get to see what posts or articles they view more and do more of those contents. When we know what makes our consumers happy, we gain an advantage for higher sales too. Customer retention is essential for any business. Since our customers want and need a change from time to time, finding out if they are happy with our products and services can sometimes be difficult. However, it is absolutely worth all the effort. When we know what makes them happy, we can align our marketing campaigns and the products we offer to those wants. We can offer them services or products according to their wants – which simply means they would not be able to say no.Read more: 4 Ways to Improve Customer Engagement Across All Channels customer engagementcustomer retentionData QualityMarketing DecisionsVisitor Analyticswebsite analytics Previous ArticleFormulus Black Partners with Looker to Improve Data Science Team ProductivityNext ArticleTechBytes with Frank Palermo, Global Head of Digital Solutions at Virtusalast_img read more

Mechanism underlying impaired allergic inflammation in children may explain hygiene hypothesis

first_imgReviewed by Kate Anderton, B.Sc. (Editor)Jan 9 2019The hygiene hypothesis says increased sanitation in industrialized countries has led to increases in asthmaThe hygiene hypothesis may explain why asthma and other allergic airway diseases have dramatically increased over the past decades in industrialized countries. The hypothesis suggests that decreased exposure to microbial products in our cleaner homes and environments — due to improved sanitation or no longer growing up on farms — is the main driver of increased allergic airway disease.But how could less exposure to infectious agents or parasites lead to more asthma? Research published in the journal Immunity by Beatriz León, Ph.D., and colleagues at the University of Alabama at Birmingham suggests an answer. León and colleagues describe a mechanism in a mouse model of asthma that supports the hygiene hypothesis — they found that infant mice need a higher exposure to a bacterial endotoxin, compared to adult mice, to avoid developing asthma-like reactions to house dust mites.Without the higher levels of the microbial lipopolysaccharide, or LPS, the infant mice developed allergic airway disease after repeated exposure to house dust mite, or HDM, allergen, and this window of susceptibility for allergic airway disease was open only while the mice were the equivalent ages of human infants and toddlers. The UAB researchers have detailed the mechanism underlying this window of susceptibility, which may then inform research into human disease.”When we know the mechanism, then we perhaps can intervene,” said León, assistant professor in the UAB Department of Microbiology.About 10 percent of U.S. school-aged children now have asthma, and almost all began developing the disease in very early childhood, before age 5. Asthma is marked by inflammation, spasms of the muscles around the airways and excess mucus secretion that obstruct the airways and make breathing difficult. The most common form, atopic asthma, is triggered by inhaled allergens like house dust mites, animal dander, fungal spores, and plant or tree pollen.In the mouse model, airway exposure to HDM triggers the disease. Interestingly, it was known that if HDM was given simultaneously with a dose of bacterial LPS — one of the most immunogenic substances known — the mice did not develop asthma-like disease.León and the UAB researchers took that observation further. They found that the amounts of LPS needed to prevent HDM asthma differed greatly between very young mice and adult mice. A low dose of LPS, in combination with the HDM, was sufficient to prevent asthma in adult mice; but that low dose did not prevent asthma in infant mice. Instead, very young mice needed 10 times as much LPS to prevent the HDM asthma. These different thresholds for suppression of disease by LPS led the researchers through a long series of experiments to unravel the mechanism causing this difference.Related StoriesStudy finds slime and biofilm hidden in hospital sinks, faucetsScientists study immune molecules inside mycetoma grainsCommon cold virus strain could be a breakthrough in bladder cancer treatmentThe story is complex because immune responses in mammals involve a complicated chain of cell-to-cell contacts among immune cells, migration of some of those immune cells throughout the body, and intricate “cross-talk” among cells using small protein signaling compounds called cytokines that interact with cell receptors.The end point for HDM asthma is the activation of naïve T-cells into pathogenic T helper 2 cells that cause inflammation in the airways. However, the researchers found that the different infant and adult responses to LPS was not due to any difference between the T-cells of the infants or adults. Instead, the different response was located upstream.In adult mice challenged with HDM and a low dose of LPS, migratory dendritic cells — immune cells that process the antigens from allergens or infectious microbes and present them to T-cells — was associated with upregulation the transcription factor T-bet in the dendritic cells, which caused production of the signaling compound interleukin-12. As a consequence of the interleukin, naïve T-cells interacting with the migratory dendritic cells in the adult mice upregulated the transcription factor T-bet, and that step precluded differentiation of the T-cells into inflammatory T helper 2 cells and thus prevented a subsequent pathogenic allergic response.In contrast, the migratory dendritic cells from infant mice failed to upregulate T-bet and interleukin-12 in low-LPS conditions. Thus, the naïve T-cells interacting with the migratory dendritic cells in infants failed to receive the suppressive interleukin-12 signals and did not upregulate T-bet. Without the T-bet, the T-cells fully differentiated into pathogenic T helper 2 cells.The different responses of the migratory dendritic cells turned out to be due to another cell signaling protein — tumor necrosis factor alpha. Adults rapidly produced that cytokine in response to the low-dose LPS sensitization, while infant mice had an impaired ability to produce the tumor necrosis factor alpha in response to LPS. The source of the tumor necrosis factor alpha was not specified in the UAB study, but indirect evidence points to some type of white blood cells in the lung.”Collectively,” León said, “our data demonstrate that LPS prevents T helper 2-dependent allergic responses with different thresholds in adults and infants; as such, a high content of LPS in airborne house-dust is required to mediate protection from allergic airway disease, specifically during infancy. Our data, therefore, provide a plausible mechanism underlying the higher susceptibility to allergic airway inflammation observed in children raised in uber-clean and sanitized environments.”Source: https://www.uab.edu/news/research/item/10077-mechanism-for-impaired-allergic-inflammation-in-infants-may-explain-hygiene-hypothesislast_img read more

Gut microbes could be linked to depression

first_img Source:https://www.nature.com/articles/s41564-018-0337-x Gut microbes Coprococcus and Dialister are markedly lower among those suffering from depression, 3D illustration. Image Credit: Kateryna Kon By Dr. Ananya Mandal, MDFeb 4 2019The human gut contains trillions of bacteria that form the gut microbiome or microbiota. A new research has linked the composition of this gut microbiome and depressive disorder. The study titled, “The neuroactive potential of the human gut microbiota in quality of life and depression,” was published in the latest issue of the journal Nature Microbiology this week.center_img The study led by M. Valles-Colomer used DNA sequencing to look at the composition of microbes in the gut. They analyzed the gut microbiota of over 1,000 people from their feces samples. The participants were part of the Belgium’s Flemish Gut Flora Project. The team then connected the microbiome composition of the participants with the quality of life and other factors in the participants. They used self reported and physician supplied diagnosis of depression among the participants and associated it with the gut microbial picture. The data was then validated from another cohort of 1,063 participants of the Netherlands’ LifeLines DEEP project. The final results from all the data collected was used to connect the microbiome of the gut and the functions of the central nervous system.Related StoriesPosterior parietal cortex plays crucial role in making decisions, research showsNew therapy shows promise in preventing brain damage after traumatic brain injuryStudy provides new insight into longitudinal decline in brain network integrity associated with agingLead researcher Jeroen Raes, from the department of Microbiology and Immunology at Flanders Institute for Biotechnology and the Catholic University of Leuven said, “The notion that microbial metabolites can interact with our brain — and thus behaviour and feelings — is intriguing… Until now, most of the studies were or in mice or in small-scale human studies, with mixed and contradictory results.”Results revealed that presence of two groups of bacteria, Coprococcus and Dialister were markedly lower among those suffering from depression. Both these groups of bacteria have anti-inflammatory properties. Raes said, “We also know that neuro-inflammation is important in depression. So, our hypothesis is that somehow these two are linked.”They noted that the gut microbiome indeed played a role in breaking down the metabolic product of the neurotransmitter Dopamine. This product is called 3,4-dihydroxyphenylacetic acid. This is one of the strongest evidence that connect gut microbiome and human brain function says the researchers. Although they agree that only a correlation has been found and not a cause and effect relationship. More research is needed to come to conclusions they add.According to the World Health Organization (WHO) there are 300 million people diagnosed with depressive illness across the globe. If a connection between gut microbiome and depression could be established, new avenues of therapy and management could open up believe experts. Raes said, “This paves the way for treatments in depression. One option is novel, next-generation probiotics. I really think there is a future in this: using cocktails of human-derived bacteria as treatment? – bugs as drugs, as they say.”last_img read more

Netflix CFO leaving TV streaming titan

first_img Explore further Citation: Netflix CFO leaving TV streaming titan (2018, August 13) retrieved 18 July 2019 from https://phys.org/news/2018-08-netflix-cfo-tv-streaming-titan.html Netflix chief financial officer David Wells on Monday announced plans to hand his job off to a successor and then focus on philanthropy. © 2018 AFP Wells has worked at the online television streaming titan for 14 years, the last eight of those as its top financial executive.Wells has been with 21-year-old Netflix as it has grown into the world’s first global television service and changed viewing habits with the introduction of “binge-viewing.””I’m very proud of everything we’ve accomplished,” Wells said in a release.”After discussing my desire to make a change with Reed, we agreed that with Netflix’s strong financial position and exciting growth plans, this is the right time for us to help identify the next financial leader for the company.”He noted that he would remain at Netflix until a new CFO is in place, intending the next phase of his life to focus more on philanthropy.”David has been a valuable partner to Netflix and to me,” said co-founder and chief executive Reed Hastings.”He skillfully managed our finances during a phase of dramatic growth that has allowed us to create and bring amazing entertainment to our members all over the world while also delivering outstanding returns to our investors.”US households are dropping their traditional pay TV packages at a faster rate than in the past amid a rise in streaming video services like Netflix, a survey showed in July.The report by the research firm eMarketer found the number of “cord-cutters” who have cancelled pay TV service will climb 32.8 percent this year to 33 million.The drop comes with more households turning to online services like Netflix, Amazon, YouTube and Hulu for on-demand video.Netflix shares plunged last month after the leading streaming television service said subscriber growth fell short of expectations in the recently ended quarter.Membership in the quarter grew 5.2 million to a total of 130 million, matching the same period last year but a million shy of what Netflix had forecast, according to a letter released along with earnings figures.Netflix shares lost a fraction of a percent more to $343.34 in early afternoon trading on Monday.center_img Netflix chief financial officer David Wells is stepping down Netflix effect: Cord-cutting accelerates in US market This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

The scandals bedevilling Facebook

first_img © 2018 AFP The scandals bedevilling Facebook Facebook chief executive Mark Zuckerberg said engineers discovered the breach on Tuesday, and patched it on Thursday night.”We don’t know if any accounts were actually misused,” Zuckerberg said. “We face constant attacks from people who want to take over accounts or steal information around the world.”Facebook reset the 50 million breached accounts, meaning users will need to sign back in using passwords. It also reset “access tokens” for another 40 million accounts as a precautionary measure.Here is a roundup of the scandals dogging the social media giant.Cambridge AnalyticaIn Facebook’s telling, everything goes back to 2013 when Russian-American researcher Aleksandr Kogan creates a personality prediction test app, “thisisyourdigitallife”, which is offered on the social network.Around 300,000 people download the app, authorising access to information on their profile and also to the data of their Facebook friends.In 2015 Facebook makes changes to its privacy policy and prevents third-party apps from accessing the data of users’ friends without their consent.The same year the social network discovers Kogan has passed on the information retrieved via his app to the British company Cambridge Analytica (CA), which specialises in the analysis of data and strategic communication. In 2016 CA is hired by Donald Trump’s US presidential campaign.Facebook says it was assured by CA in 2015 that the data in question had been erased. But it estimates the firm could have had access to the data of up to 87 million users, most in the United States, without their consent, and mined this information to serve the Trump campaign.Cambridge Analytica, which denies the accusations, has since filed for voluntary bankruptcy in the United States and Britain. Facebook is accused of having been lax in its protection of user data, slow to intervene and consistently vague on its privacy settings.In 2011 it signed a consent decree with US consumer protection agency the Federal Trade Commission (FTC) settling charges that it deceived consumers by telling them they could keep their information on Facebook private, and then allowing it to be shared and made public. Citation: The scandals bedevilling Facebook (2018, September 29) retrieved 17 July 2019 from https://phys.org/news/2018-09-scandals-bedevilling-facebook.html Explore further Credit: CC0 Public Domain Facebook is at the centre of controversy yet again after admitting that up to 50 million accounts were breached by hackers. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. In March this year the FTC said it had opened an inquiry into Facebook’s privacy practices, including whether the company violated the earlier agreement, which would incur hefty fines.Beyond the CA scandal, Facebook estimates the data of nearly all its users may have, at some time, been retrieved without their knowledge.Political manipulationFacebook and sites like Google, Twitter and Tumblr are also accused of having allowed the spread through their networks of “fake news”, including to manipulate public opinion ahead of the US election in favour of Trump.The sites have acknowledged finding on their platforms messages, accounts and pages associated with the Internet Research Agency, a Saint Petersburg operation that is alleged to be a “troll farm” connected to the Russian government.It is accused of spreading disinformation and propaganda including via postings—often in the form of sponsored ads that target users based on their personal data—that could influence opinion, for example over immigration. According to Facebook, more than 120 million users had seen such content.Facebook is in particular accused of not having been vigilant enough on monitoring the content and authenticity of pages and political ads that it carries.It announced this year that it will require that the sponsors of political ads are identified and verified.Earlier this month, Zuckerberg said Facebook was better prepared to defend against efforts to manipulate the platform to influence elections.”We’ve identified and removed fake accounts ahead of elections in France, Germany, Alabama, Mexico and Brazil,” Zuckerberg said.”We’ve found and taken down foreign influence campaigns from Russia and Iran attempting to interfere in the US, UK, Middle East, and elsewhere—as well as groups in Mexico and Brazil that have been active in their own country.”last_img read more

Intel announces Israel expansion government values at 10 bn

first_img Citation: Intel announces Israel expansion government values at $10 bn (2019, January 29) retrieved 17 July 2019 from https://phys.org/news/2019-01-intel-israel-expansion-values-bn.html Intel, which already employs nearly 13,000 staff in Israel, either directly or through its autonomous technology subsidiary Mobileye, has announced a major expansion the government values at some $10 billion dollars Intel to pump $6 bn into Israel Explore further © 2019 AFPcenter_img Intel said Tuesday it is expanding its operations in Israel, where government ministers said the US computer chipmaker will invest some 10 billion dollars in a new plant. “Intel today announced it will submit a business plan to the government of Israel for continued investment in the company’s Kiryat Gat manufacturing site,” a statement from Intel’s Israeli representatives said.Finance Minister Moshe Kahlon said late Monday he was informed by Intel of their decision “to invest another 40 billion shekels, an unprecedented decision expected to bring thousands of jobs to the south.”Economy Minister Eli Cohen said Intel had chosen to “build its most advanced plant here in Israel.”Last year, Intel had already decided on a $5 billion upgrade to the site in Kiryat Gat, a small city in southern Israel. In 2017, Intel closed a $15 billion deal to buy Israeli autonomous technology firm Mobileye, the country’s biggest cross-border high-tech deal ever.The Silicon Valley giant currently employs 11,700 people in Israel in its Kiryat Gat plant and development centres across the country, in addition to 1,170 Mobileye staff.Intel’s exports from Israel reached $4 billion in 2018, according to the company. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Mumbai Unable to locate 3yearold Divyansh who fell into gutter search teams

first_imgMumbai: Unable to locate 3-year-old Divyansh who fell into gutter, search teams call off operationsThe search for a three-year-old boy who fell into an open stormwater drain here on Wednesday has been stopped, a civic official said on Friday night.advertisement Next Press Trust of India MumbaiJuly 12, 2019UPDATED: July 12, 2019 23:06 IST Divyansh Singh, who fell into a drain at Ambedkar Chowk in Malad East around 10 pm Wednesday, remained untraceable even after 48 hours.The search for a three-year-old boy who fell into an open stormwater drain here on Wednesday has been stopped, a civic official said on Friday night.Divyansh Singh, who fell into a drain at Ambedkar Chowk in Malad East around 10 pm Wednesday, remained untraceable even after 48 hours.The search was finally stopped around 10 pm, the spokesperson of the Brihanmumbai Municipal Corporation (BMC) said.The search team covered over 10 km of drainage line but in vain, another official said.The team of 50 BMC, Fire Brigade and National Disaster Response Force personnel searched the drain line by opening all manholes along the stretch.The child’s fall into the drain near Goregaon-Mulund Link Road was captured by CCTV cameras.Divyansh’s father Suraj Bhan Singh had alleged earlier that the authorities were not doing enough to trace his son.”The BMC, fire brigade and NDRF are not showing any intent to find my son. The fire brigade team did not even have a torch. NDRF jawans came and went back after marking their presence. Our family wanted to protest but were stopped by the police,” Singh had claimed.He also hit out at Mumbai Mayor Vishwanath Mahadeshwar for not bothering to meet him or other members of the family.ALSO READ | 20 hours on, no trace of Mumbai toddler who fell down gutter, family inconsolableALSO WATCH | 2-year-old falls into open drain in MumbaiFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byAnupriya Thakur Tags :Follow Mumbailast_img read more